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Dermatology

Issue


  • Dermatology
  • Autoimmune Blistering Skin Diseases

Personal Data


Dr. med. Silke Hofmann


Department


Molecular Dermatology, Department of Dermatology, University Medical Center Freiburg



Know-How


  • Development of diagnostic ELISAs for detection of autoantibodies in patients sera (collagen XVII, collagen VII)
  • Biochemical methods like immunoblot, immunoprecipitation, protein expression and purification
  • Development of monoclonal antibodies




Selected Publications


1. Hofmann SC, Thoma-Uszynski S, Hunziker T, Bernard P, Koebnick C, Stauber A, Schuler G, Borradori L, Hertl M: Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2 – and COOH-terminal regions of the BP180 ectodomain. J Invest Dermatol 2002; 119: 1065-1073

2. Hofmann SC, Tamm K, Hertl M, Borradori L: Diagnostic value of an enzyme-linked immunosorbent assay using BP180 recombinant proteins in elderly patients with pruritic skin disorders. Br J Dermatol 2003; 149: 910-911

3. Seppänen A, Suuronen T, Hofmann SC, Majamaa K, Alafuzoff I: Distribution of collagen XVII in the human brain. Brain Res 2007; 1158:50-56.

4. Hofmann SC, Voith U, Sasaki T, Trüeb RM, Nischt R, Bruckner-Tuderman L: The autoantigen in anti-p200 pemphigoid is synthesized by keratinocytes and fibroblasts and is distinct from nidogen-2. J Invest Dermatol 2008; 128:87-95.

5. Hofmann SC, Technau K, Müller AMS, Lübbert M, Bruckner-Tuderman L: Bullous pemphigoid associated with hypereosinophilic syndrome: simultaneous response to imatinib.

J Am Acad Dermatol 2007; 56:S68-72.




Projects


  • Characterization of the p200-autoantigen in anti-p200 pemphigoid
  • Development and functional characterization of monoclonal antibodies against collagen XVII
  • Analysis of blister fluids for the presence of collagen XVII
  • Analysis of collagen XVII in human brain
  • Antimicrobial peptides in Staph. aureus colonization and infection
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