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Neuropharmacology

Issue


In vitro-experiments on human neocortex tissue: Release of neurotransmitters, evaluation of mitochondrial ROS generation, isolation and analysis of microvessel endothelial cells.


Personal Data


Thomas J. Feuerstein, Prof. Dr.


Department


Sektion Klinische Neuropharmakologie der Neurochirurgischen Universitätsklinik (University Medical Center)


Know-How

Working areas:

  • Neurotransmitter release from brain tissue and its modulation
  • Theory of receptors
  • Epilepsy
  • Neuroprotection, cytotrophic effects of GABA-lactam analogues

Technologies:

  • Uptake and superfusion experiments on brain slices and synaptosomes
  • Binding studies on pre- and postsynaptic membranes
  • Isolation of microvessel endothelial cells from human brain tissue
  • Evaluation of reactive oxigen species in mitochondria


Publications


See publication list


Projects


  • Osteoblast proliferation and mitochondrial reactive oxygen species upon GABA lactam analogues
  •  Design, synthesis and pharmacological evaluation of potentially neuroprotective and anticonvulsant compounds



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