Neuropharmacology
Issue
In vitro-experiments on human neocortex tissue: Release of neurotransmitters, evaluation of mitochondrial ROS generation, isolation and analysis of microvessel endothelial cells.
Personal Data
Thomas J. Feuerstein, Prof. Dr.
Department
Sektion Klinische Neuropharmakologie der Neurochirurgischen Universitätsklinik (University Medical Center)
Know-How
Working areas:
- Neurotransmitter release from brain tissue and its modulation
- Theory of receptors
- Epilepsy
- Neuroprotection, cytotrophic effects of GABA-lactam analogues
Technologies:
- Uptake and superfusion experiments on brain slices and synaptosomes
- Binding studies on pre- and postsynaptic membranes
- Isolation of microvessel endothelial cells from human brain tissue
- Evaluation of reactive oxigen species in mitochondria
Publications
See publication list
Projects
- Osteoblast proliferation and mitochondrial reactive oxygen species upon GABA lactam analogues
- Design, synthesis and pharmacological evaluation of potentially neuroprotective and anticonvulsant compounds